The challenge of drug resistance in parasites
網頁BACKGROUND: New anti-malarial drugs are needed urgently to address the increasing challenges of drug-resistant falciparum malaria. ... Parasites were more sensitive to analogue 2: IC50 48.6-63.3 nM (median = 52.2 nM). Similar results were obtained against ... 網頁Here, we review recent advances in our understanding of CQ resistance and discuss these in the broader context of the parasite's susceptibilities to other quinolines and related …
The challenge of drug resistance in parasites
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網頁2024年2月28日 · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In … 網頁The control of infectious diseases is seriously threatened by the steady increase in the number of micro-organisms that are resistant to antimicrobial agents—often to a wide range of these agents. Resistant …
網頁Background Cambodia is the epicentre of the emergence of Plasmodium falciparum drug resistance. Much less is known regarding the drug susceptibility of the co-endemic Plasmodium vivax. Only in vitro drug assays can determine the parasite’s intrinsic susceptibility, but these are challenging to implement for P. vivax and rarely performed. … 網頁Mentioning: 130 - This review will focus on two general approaches carried out at the Sandler Center, University of California, San Francisco, to address the challenge of developing new drugs for the treatment of Chagas disease. The first approach is target-based drug discovery, and two specific targets, cytochrome P450 CYP51 and cruzain …
網頁2024年9月17日 · Abstract. Typhoid, and its extra drug resistant form which is highly prevalent Pakistan, is increasing the burden on healthcare through multiple factors. These range from lack of sanitation, the collapsing economy, and poor access to clean drinking water which have made it arduous for the government and various other organizations in … 網頁Gastrointestinal nematodes (GIN) are a major challenge for sheep producers worldwide. They cause a variety of clinical signs and large economic impact. Anthelmintics are …
網頁iv 5. Data on antimalarial drug efficacy and drug resistance (2010–2024) 25 5.1 Summary 255.2 WHO African Region 275.2.1 WHO African Region: Central Africa 27 5.2.2 WHO African Region: Eastern and Southern Africa 29 5.2.3 …
網頁2013年10月1日 · The spread of resistant parasite strains elsewhere, including Africa, has been well documented retrospectively with molecular markers of the resistance to each drug [3, 4, 5]. After chloroquine and sulphadoxine–pyrimethamine failures, Thailand introduced mefloquine as the first-line drug for uncomplicated falciparum malaria. hyperopt partial網頁2024年1月14日 · Sequencing large numbers of individual samples is often needed for countrywide antimalarial drug resistance surveillance. Pooling DNA from several individual samples is an alternative cost and time saving approach for providing allele frequency (AF) estimates at a population level. Using 100 individual patient DNA samples of dried blood … hyperopt lightgbm網頁Over the past six decades, the drug resistance of Plasmodium falciparum has become an issue of utmost concern. ... introduction of artemisinin-based combi … Challenges of … hyperopt library網頁Drug resistance is a fundamental factor in treatment failure in diseases like leishmaniasis, although additional factors also play a role in this phenomenon. This volume is the … hyper optix網頁2012年9月6日 · Multidrug-resistant (MDR) tuberculosis — by convention, a disease caused by strains of Mycobacterium tuberculosis that are resistant to isoniazid and rifampin, the backbone of first-line ... hyperopt mongodb網頁2024年4月9日 · Drug resistance threatening humans may be linked with antimicrobial and anthelmintic resistance in other species, especially among farm animals and, more in general, in the entire environment. From this perspective, Green Veterinary Pharmacology was proven successful for the control of parasites in small ruminants and for the control … hyperopt machine learninghyperopt pip install