WebbThe mitochondrial carnitine/acylcarnitine carrier (CAC) transports short-, medium- and long-carbon chain acylcarnitines across the mitochondrial inner membrane in exchange for carnitine. How CAC recognizes the substrates with various fatty acyl groups, especially long-chain fatty acyl groups, remains unclear. Here, using nuclear magnetic resonance … WebbMoreover, oligosaccharides distributed to an mitochondria after internalization into C2C12 dungeons and increased the expression of transcriptional governors peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), carnitine palmitoyl transferase-1 (CPT-1), and phosphorylated acetyl-CoA carboxylase (p-ACC), which suggested that the …
Mechanisms of Protein Import into Mitochondria - ScienceDirect
WebbCharcot-Marie-Tooth (CMT) disease is one of the most common heritable neuromuscular disorders, affecting 1 in every 2500 people. Mutations in LITAF have been shown to be causative for CMT type 1C disease. In this paper we explore the subcellular localization of wild type LITAF and mutant forms of LITAF known to cause CMT1C (T49M, A111G, … Webb14 apr. 2024 · Abstract The processes of biotransformation of pantothenic acid (Pan) in the biosynthesis and hydrolysis of CoA, key role of pantothenate kinase (PANK) and CoA synthetase (CoASY) in the formation of the priority mitochondrial pool of CoA, with a high metabolic turnover of the coenzyme and limited transport of Pan across the blood-brain … h. p. grice の会話の公理 maxims of conversation
[Lysosomal storage diseases--an overview]. Semantic Scholar
Webb11 apr. 2024 · Lewy bodies are intracellular aggregates containing various proteins including α-synuclein which can become misfolded and self-aggregated. Systems in place to break down abnormal proteins like ubiquitin-proteasome are also impaired, leading to depressed neural functioning [6]. http://vcell.ndsu.edu/animations/mito-pt/ Webb7 feb. 2024 · Mitochondria further depend on the import of about 1,000 types of protein from the cytosol. The translocase of the outer membrane, also termed TOM complex, … hpg recon kit bag