Lamp2b是什么蛋白
Tīmeklis载体简介 载体序列 LOCUS pcDNA GNSTM-3-RVG-10-Lamp2b-HA 6988 bp ds-DNA circular SYN 06-AUG-2024 DEFINITION Encodes (N to C): GNSTM glycosylation motif, 3 residue spacer, RVG peptide, 10 residue spacer, Lamp2b (exosomal transmembrane protein), 3 residue spacer, HA tag.. ACCESSION . VERSION . Tīmeklis2024. gada 24. dec. · Here, we demonstrate that LAMP-2B promotes autophagosome–lysosome fusion in cardiomyocytes (CMs), independently of STX17. …
Lamp2b是什么蛋白
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TīmeklisReceive email alerts when new plasmids with this gene become available. Log in to subscribe to Addgene Alerts. Description lysosomal associated membrane protein 2. Also known as CD107b, DND, LAMP-2, LAMPB, LGP-96, LGP110. Species Homo sapiens. Entrez ID 3920. MGC ID BC002965. Tīmeklis2024. gada 12. dec. · 但他们没有研究RVG-Lamp2b融合蛋白是否诱导重复给药后的适应性免疫。 事实上，很可能会产生适应性免疫反应。 另一个未被研究者解决的问题是，受阿尔茨海默病影响的大脑中，用于使外泌体靶向大脑的RVG的受体，即α-7-亚基乙酰胆碱受体，明显减少。 这个问题在开发包含抗BACE1 siRNA的RVG-外泌体用于阿尔茨 …
Tīmeklis2024. gada 6. sept. · HuR Lamp2b exosomes lysosome protein delivery Introduction RNA metabolism is a stepwise process, including transcription, pre-mRNA processing, mRNA export, subcellular localization, translation and degradation. Specific degradation of target mRNAs holds great importance for gene therapy. Tīmeklis2024. gada 15. dec. · Abstract. Huntington’s disease is an autosomal-dominant neurodegenerative disease caused by CAG expansion in exon 1 of the huntingtin (HTT) gene.Since mutant huntingtin (mHTT) protein is the root cause of Huntington’s disease, oligonucleotide-based therapeutic approaches using small interfering RNAs …
TīmeklisAn increase in LAMP2B transcript was seen only in mice treated with 2 × 10 14 vg/kg AAV9.LAMP2B versus PBS controls at the 12-week time point, which was consistent with the biodistribution/VCN data, indicating that higher vector doses are necessary to enable efficient expression of LAMP2B in skeletal muscle compared with the liver … Tīmeklis2024. gada 15. nov. · 细胞外小囊泡（sEVsRVG）的脑部神经特异性靶向是通过将sEVs膜蛋白lamp2b和神经靶向性的狂犬病毒糖蛋白衍生肽（RVG）融合递呈在细胞外囊泡上，在细胞及动物水平验证了sEVsRVG-siRNA的抗病毒能力 图3： sEVsRVG-siRNA装载siRNA条件的优化及其在细胞水平上的抗病毒能力 图4：孕鼠模型证明 …
Lysosome-associated membrane protein 2 (LAMP2), also known as CD107b (Cluster of Differentiation 107b) and Mac-3, is a human gene. Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins. The protein encoded by this gene is a member of a family of membrane glycoproteins. This … Skatīt vairāk The gene for LAMP2 has 9 coding exons and 2 alternate last exons, 9a and 9b. When the last exon is spliced with the alternative exon, it is a variant called LAMP2b, which varies in the last 11 amino acids of its C … Skatīt vairāk Lysosomes are cell organelles found in most animal cells. Their main functions center around breaking down materials and debris in the cell. Some of this is done via acid hydrolases that degrade foreign materials and have specialized autolytic functions. These … Skatīt vairāk • Cluster of differentiation Skatīt vairāk • LAMP2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • PDBe-KB provides an … Skatīt vairāk LAMP2 has been specifically implicated in tumor cell metastasis. Both LAMP1 and LAMP2 have been found expressed on the surface of … Skatīt vairāk • CA77.1 • QX39 Skatīt vairāk • Chang MH, Karageorgos LE, Meikle PJ (2003). "CD107a (LAMP-1) and CD107b (LAMP-2)". Journal of Biological Regulators and … Skatīt vairāk
Tīmeklis2024. gada 24. nov. · Lamp2b-HuR融合蛋白功能化的外泌体能够将被RNA结合基序识别的RNA靶标驱动至溶酶体以在受体细胞中降解。 该系统在富含溶酶体的巨噬细胞中 … luxury leather jotterTīmeklis一种基于Lamp2b的融合蛋白可用于在表面显示狂犬病病毒糖蛋白（RVG），当这些胞外体被系统地给予时，表面展示的RVG导致这些胞外体在小鼠的神经元和大脑中积聚 … luxury leather jacketsTīmeklisPlasmid pcDNA GNSTM-3-RVG-10-Lamp2b-HA from Dr. Joshua Leonard's lab contains the insert Lamp2b and is published in J Biol Chem. 2015 Mar 27;290(13):8166-72. doi: 10.1074/jbc.M114.621383. Epub 2015 Feb 5. This plasmid is … king of prussia pa to conshohocken pahttp://www.biofeng.com/adjy/zhili/pcDNA%20Flag%20Lamp2b-HA.html king of prussia pa to downingtown paTīmeklis2024. gada 1. febr. · The pEGFP-C1-RVG-Lamp2b expressing vector was kindly provided by Prof. Matthew J A Wood’ lab from University of Oxford [70]. DNA sequence encoding the glycosylation sequon (GNSTM), E7 Peptide [55] and a glycine-serine spacer were synthesized and subcloned to replace the RVG fragment by XhoI/BspeI … luxury leather keyringTīmeklis2024. gada 25. marts · In addition, images also showed that LAMP2B colocalization with LAMP2A is lower than expected (73.88 ± 13.09%), indicating that both LAMP2 … luxury leather jewellery boxTīmeklis2024. gada 15. okt. · LYSOSOME-ASSOCIATED MEMBRANE PROTEIN 2; LAMP2 Alternative titles; symbols LYSOSOME-ASSOCIATED MEMBRANE PROTEIN B; … king of prussia pa to trenton