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WebSep 21, 2009 · Osteoarthritis (OA) is a very common chronic disease that affects all joint tissues, causing progressive irreversible damage and, finally, the failure of the joint as an organ [].Characteristic pathological changes in OA not only include joint cartilage degeneration but also subchondral bone thickening, osteophyte formation and synovial … WebDec 21, 2024 · Osteoarthritis (OA) is a degenerative joint disease that affects the cartilage, synovium, and subchondral bone and is the leading cause of disability in older populations. Specific diagnostic biomarkers are lacking; hence, treatment options for OA are limited. ... ERK, and NF-κB on the MMP-3 promoter through CX3CR1, thus contributing to ... WebOct 9, 2024 · ERK pathway may play a protective role on the NO-induced chondrocyte apoptosis, and inhibition of ERK pathway enhances the NO-induced apoptosis. Nitric oxide (NO) and reactive oxygen species (ROS) play an important role in the pathology of … blackwater meadow marina shropshire