Dystonin (DST), also known as bullous pemphigoid antigen 1 (BPAG1), isoforms 1/2/3/4/5/8, is a protein that in humans is encoded by the DST gene. This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct … See more Dystonin has been shown to interact with collagen, type XVII, alpha 1, DCTN1, MAP1B and erbin. See more Several Dst mutant mouse lines have been described which share the common feature of having sensory neuron degeneration. In … See more • Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones" See more • Bullous pemphigoid See more WebMay 25, 2024 · HSAN-VI, perhaps the most notable type, is an autosomal recessive disease, which manifests as the severely impaired pain sensitivity, autonomic disturbances, distal myopathy, spontaneous or surgical amputations, and sometimes early death. Mutations in DST have been identified as the cause of HSAN-VI. DST encodes …
Dystonin - Wikipedia
WebDec 21, 2024 · 90 Defects in cell adhesion and migration consequent to Dystonin pathogenic variations may interfere with ... neurons express dystonin/Bpag1 and that loss of this expression causes an increase in ... WebHFFF2 cells were infected with 1 PFU/cell of vSR27-VP26GFP or vFR ⌬ 37-VP26GFP. Sixteen hours later, cells were fixed and endogenous dystonin was visualized using specific antibodies DST and GAR ... taranis configuration helper console
Dystonin Antibody (H10D.Hy.8B) - Novus Biologicals
WebIn the present study, we show that bpag1 is expressed in the mouse F10 melanoma cell line in vitro and F10 melanoma tumors in vivo and that BPAG1 is expressed in human melanoma cell lines (A375 and G361) and normal human melanocytes. Moreover, the levels of anti-BPAG1 auto-antibodies in the sera of melanoma patients were significantly higher ... WebOct 25, 2024 · This protein is expressed on many types of cells including antigen-presenting cells (APCs), T cells, B cells, monocytes, and epithelial cells. After activation in response to pro-inflammatory cytokines, these cells upregulate the expression of PD-1 [ 3, 4, 5 ]. WebOct 19, 2015 · The latter, now called dystonin (DST), is composed of at least 100 exons and gives rise to three major isoforms, an epithelial, a neuronal and a muscular isoform, … taranis cxsrw66ml