Carboxymethylproline
WebOct 14, 2005 · Formation of carboxymethylproline (t-CMP) 2 the β-amino acid precursor of the first formed β-lactam ((3S,5S)-carbapenam-3-carboxylate) is catalyzed by a member … WebCarboxymethylproline synthase (CarB) catalyzes the committed step in the biosynthesis of ( R )-1-carbapen-2-em-3-carboxylate, the simplest member of the carbapenem family of β-lactam antibiotics, some of which are used clinically.
Carboxymethylproline
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WebApr 1, 2005 · Carboxymethylproline synthase was shown to condense L-glutamate semialdehyde with malonyl-coenzyme A to produce (2S,5S)-carboxymethylproline, while incubation of D-glutamate semialdehyde... WebFeb 20, 2004 · Carboxymethylproline synthase (CarB) catalyzes the committed step in the biosynthesis of (R)-1-carbapen-2-em-3-carboxylate, the simplest member of the …
WebEnzyme in action: Labeling studies and the finding that carboxymethylproline synthase catalyzes production of deuterated (2S,5S)-6,6′-dimethyl-trans-carboxymethylproline (3) from dimethylmalonyl-CoA (1) and labeled l-pyrroline-5-carboxylate (2) limit possible mechanisms of C C bond formation and thioester hydrolysis. WebCOVID Moonshot: Open Science Discovery of SARS-CoV-2 Main Protease Inhibitors by Combining Crowdsourcing, High-Throughput Experiments, Computational Simulations, and Machine Learning
WebJul 7, 2005 · carboxymethylproline synthase (CarB) from pectobacterium carotovora, complexed with acetyl CoA and bicine. PDB DOI: 10.2210/pdb2A81/pdb; Classification: … Webthe carboxymethylproline ring are discussed in the light of the structures and the accompanying studies using isotopically labeled substrates; cyclization via 1,4-addition is …
WebRole of carboxymethylproline synthases in carbapenem biosynthesis and CarB engineering. (A) Biosynthesis of the simplest carbapenem as catalyzed by the crotonase …
WebCarboxymethylproline synthase was shown to condense L-glutamate semialdehyde with malonyl-coenzyme A to produce (2S,5S)-carboxymethylproline, while incubation of D-glutamate semialdehyde results only in uncoupled turnover of malonyl-CoA. Publication types Evaluation Study Research Support, Non-U.S. Gov't computer problem busters st louisWebNov 7, 2024 · Carbapenems are biologically mainly active in the infections like urinary tract infections, bloodstream infections, tuberculosis, intra-abdominal infections, and pathogens like anaerobes, gram-positive and gram-negative bacteria. Keywords: Carbapenem, antibiotics, structure, chemistry, resistance, mechanism of action. « Previous Next » eco footprintscomputer problem busters incWebCarboxymethylproline synthase Gene carB Status UniProtKB reviewed (Swiss-Prot) Organism Pectobacterium carotovorum subsp. carotovorum (Erwinia carotovora subsp. … computer probleme behebenWebCarboxymethylproline synthase (CarB) catalyzes the committed step in the biosynthesis of (R)-1-carbapen-2-em-3-carboxylate, the simplest member of the carbapenem family of β … computer problem chat roomsWebOct 14, 2005 · CarB catalyzes formation of (2 S ,5 S )-carboxymethylproline [ (2 S ,5 S )- t -CMP] from malonyl-CoA and l -glutamate semialdehyde. In addition to using a cosubstrate, CarB catalyzes C-C and C-N bond formation processes as well as an acyl-coenzyme A hydrolysis reaction. computer problem and solutionWebJul 18, 2003 · Total Structure Weight: 227.03 kDa Atom Count: 16,279 Modelled Residue Count: 2,000 Deposited Residue Count: 2,012 Unique protein chains: 1 Display Files Download Files 1Q19 Carbapenam Synthetase PDB DOI: 10.2210/pdb1Q19/pdb Classification: BIOSYNTHETIC PROTEIN Organism (s): Pectobacterium carotovorum … eco footprints kamloops